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Ghigo E, Arvat E, Rizzi G, et al
A vast evidence supports the occurrence of reactions of metal ions with H 2 O 2 , and hydroperoxides in the cytosol and in biological membranes
This hypothesis is further supported when the osteogenic differentiation promoted by MOTS-c is reversed upon TGF-1 knockdown, indicating that MOTS-c's actions may be at least partly mediated through the TGF-/Smad pathway
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